azathioprine side effects

Azathioprine may affect your liver function and blood counts. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. What is the most important information I should know about azathioprine (Azasan, Imuran)? Neutropenia and thrombocytopenia Neutropenia is dose-dependent. Snow JL, Gibson LE "A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients." Ann Intern Med 104 (1986): 651-5, 68. You may report side effects to FDA at 1-800-FDA-1088. If you notice any other effects, check with your healthcare professional. Nephron 63 (1993): 471, 20. Some people can have serious side effects when taking azathioprine. "Epstein-Barr Virus-Positive Lymphoma in Patients With Inflammatory Bowel Disease Treated With Azathioprine or 6-Mercaptopurine." Apo-Azathioprine: Azathioprine belongs to the group of medications known as immunosuppressive agents. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. If you are using azathioprine for arthritis, make sure your doctor knows if you had received chlorambucil (Leukeran®), cyclophosphamide (Cytoxan®, Neosar®), or melphalan (Alkeran®) to treat your arthritis in the past. Excess sun exposure, pale skin types, and duration of allograft seem to be important risk factors in the development of skin lesions. These side effects may go away during treatment as your body adjusts to the medicine. Frequency and severity of side effects depend on dose and duration of azathioprine as well as on underlying disease or concomitant therapies. Do not take other medicines unless they have been discussed with your doctor. Fever. Jayne1863 • • 6 Replies. Available from: URL: http://www.tga.gov.au/adr/aadrb/aadr0612.htm." Her creatinine was 119 mcmol/L at the time of presentation. Keep from freezing. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. J Intern Med 227 (1990): 69-72, 8. Objective: In clinical trials 0-15% of patients discontinued azathioprine due to side effects. Lancet 347 (1996): 215-9, 17. However everyone reacts differently to medicines and it is very unlikely that you will have all the listed effects. Increased risk of infection and hepatotoxicity. A single-centre experience from Australia." Br J Dermatol 133 (1995): 460-2, 49. Dayharsh GA, Loftus EV Jr, Sandborn WJ, et al. N Engl J Med 359 (2008): 1524-6, 70. Elijovisch F, Krakoff LR "Captopril associated granulocytopenia in hypertension after renal transplantation." Liano F, Moreno A, Matesanz R, et al "Veno-occlusive hepatic disease of the liver in renal transplantation: is azathioprine the cause?" O 0, 76. de Fonclare AL, Khosrotehrani K, Aractingi S, Duriez P, Cosnes J, Beaugerie L "Erythema Nodosum-like Eruption as a Manifestation of Azathioprine Hypersensitivity in Patients With Inflammatory Bowel Disease." Azathioprine sometimes causes nausea or vomiting. Keystone EC, Schabas R "Hypotension with oliguria: a side-effect of azathioprine." Safety / Side Effects . J R Soc Med 78 (1985): 1052-3, 78. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. It is very important that your doctor check your progress at regular visits for any problems that may be caused by this medicine. Erythema nodosum and pustules may be related to the clinical activity of inflammatory bowel disease. Cerner Multum, Inc. "UK Summary of Product Characteristics." See below for a comprehensive list of adverse effects. Pozniak AL, Ahern M, Blake DR "Azathioprine-induced shock." liver damage. Wear protective clothing and hats, and stay out of direct sunlight between the hours of 10 am and 3 pm Avoid sunlamps and tanning beds. Br Med J 283 (1981): 1548, 30. The most common side effects of azathioprine are nausea and feeling unwell or feeling. Small P, Lichter M "Probably azathioprine hepatotoxicity: a case report." In fact, I'm sicker now on it. Azathioprine may cause a rare type of lymphoma ( cancer ) of the liver , spleen, and bone marrow that can be fatal. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Lancet 342 (1993): 1245-6, 10. If you have questions about this, talk to your doctor. [Ref], Very common (10% or more): Nausea, vomiting, Uncommon (0.1% to 1%): Diarrhea, pancreatitis, steatorrhea, Rare (less than 0.1%): Colitis (transplant recipients), diverticulitis or intestinal perforation (transplant recipients), gastrointestinal ulcers (transplant recipients), intestinal hemorrhage (transplant recipients), necrosis (transplant recipients), severe diarrhea (inflammatory bowel disease patients), Frequency not reported: Severe villus, sores in the mouth and on the lips[Ref]. Barreto SG, Tiong L, Williams R "Drug-induced acute pancreatitis in a cohort of 328 patients. Pharmacotherapy 17 (1997): 815-8, 84. Azathioprine gets broken down in the body by proteins called enzymes. The aim of this study was to assess the rate of side effects leading to discontinuation of azathioprine and to determine predictive factors for discontinuation. Adults—Dose is based on body weight and must be determined by your doctor. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Azathioprine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Chronic immunosuppression with azathioprine increases risk of malignancy in humans. N Engl J Med 289 (1973): 357, 29. Ten weeks after starting azathioprine 100 mg per day, a full blood count (during routine monitoring) showed moderate pancytopenia. If you notice any other effects, check with your healthcare professional. See "What Are Side Effects Associated with Using Azathioprine?" The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Serious side effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Benari Z, Mehta A, Lennard L, Burroughs AK "Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis." [Ref], Rare (less than 0.01%): Hypotension, including cardiogenic shock, Frequency not reported: Atrial fibrillation[Ref], Frequency not reported: Exacerbation of dermatomyositis, rash, Sweet's syndrome (acute febrile neutrophilic dermatosis)[Ref]. Gastrointestinal side effects tend to be more problematic in the first few months of therapy. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. The effects may be increased because of slower removal of the medicine from the body. Idiosyncratic manifestations of hypersensitivity include general malaise, headache, dizziness, nausea, vomiting, diarrhea, fever, rigors, exanthema, rash, vasculitis, myalgia, arthralgia, hypotension, renal dysfunction, hepatic dysfunction, cardiac dysrhythmia, and cholestasis. Complications such as colitis, diverticulitis, and bowel perforation have been primarily reported in transplant patients, and may be related to concomitant high-dose corticosteroid therapy. Portions of this document last updated: Sept. 01, 2020, Original article: https://www.mayoclinic.org/drugs-supplements/azathioprine-oral-route/side-effects/drg-20067180. Azathioprine Side Effects. Dig Dis Sci 29 (1984): 78-80, 41. Med J Aust 190 (2009): 341-2, 48. Transplantation 76 (2003): 265-6, 19. Azathioprine Side Effects See also Warning section. These could be symptoms of a serious reaction to the medicine in your bowel. received an overall rating of 9 out of 10 stars from 3 reviews. Or R, Kleinman Y, Chajek-Shaul T "Azathioprine and urinary bladder tumor." All drugs may cause side effects. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Escousse A, Mousson C, Santona L, Zanetta G, Mounier J, Tanter Y, Duperray F, Rifle G, Chevet D "Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: a family study." A 52-year-old male with steroid-dependent ulcerative colitis experienced atrial fibrillation coincident with azathioprine therapy. 4.2 Posology and method of administration. N Engl J Med 287 (1972): 292-4, 90. Am J Gastroenterol 98(9S) (2003): S242, 2. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else. Medically reviewed by Drugs.com. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Do not get close to them and do not stay in the same room with them for very long. J Am Acad Dermatol 32 (1995): 114-6, 4. Millard PR, Herbertson BM, Evans DB, Calne RY "Azathioprine hepatotoxicity in renal transplantation." The diarrhea is horrible. If you have any of these effects you do not need contact the doctor unless they persist for more than a few days or become unbearable. Take azathioprine with food. Do not treat yourself. Medically reviewed by. She was diagnosed with ulcerative colitis at age 16. Find treatment reviews for Azathioprine from other patients. Amber J. Tresca. Kidney Int 64 (2003): 1027-34, 93. Know Azathioprine 50 MG Tablet uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on Lybrate.com J R Soc Med 85 (1992): 752-6, 7. Neurology 38 (1988): 258-61, 11. Side effects that are probably hypersensitivity reactions include dizziness, diarrhea, fatigue, and skin rashes. This is not a complete list of side effects and others may occur. Few treatments are without risk. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Katska DA, Saul SH, Jorkasky D, Sigal H, Reynolds JC, Soloway RD "Azathioprine and hepatic venocclusive disease in renal transplant patients." Read AE, Wiesner RH, LaBrecque DR, et al "Hepatic veno-occlusive disease associated with renal transplantation and azathioprine therapy." Bone marrow aplasia has been reported in patients with normal TPMT activity. Cassinotti A, Massari A, Ferrara E, et al. Ask your healthcare professional how you should dispose of any medicine you do not use. Arch Dermatol 132 (1996): 1254-5, 82. Kerstens PJSM, Stolk JN, Deabreu RA, Lambooy LHJ, Vandeputte LBA, Boerbooms AAMT "Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis." BRAND NAME(S): Imuran. Azathioprine has a number of side effects. Taking this medicine after meals, in divided doses, or at bedtime may lessen stomach upset. Azathioprine may cause side effects. Diarrhea completely resolved within 2 weeks after azathioprine discontinuation. Along with its needed effects, azathioprine may cause some unwanted effects. Azathioprine works to reduce your immune system. Cerner Multum, Inc. "Australian Product Information." Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Ask your doctor to help you plan a way to remember to take your medicines at the right times. Azathioprine Genetic Information. Notify your doctor if you experience yellow coloured skin or eyes or stomach or abdominal pain. Gut 29 (1988): 686-8, 27. She continued to have reasonable renal function and 16 months later had creatinine of 104 mcmol/L with no clinical evidence of recurrent interstitial nephritis. McHenry PM, Allan JG, Rodger RS, Lever RS "Nephrotoxicity due to azathioprine." Konstantopoulou M, Belgi A, Griffiths KD, Seale JR, Macfarlane AW "Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase." Gastroenterology 86 (1984): 162-5, 63. Cooper C, Minihane N, Cotton DW, Cawley MI "Azathioprine hypersensitivity manifesting as acute focal hepatocellular necrosis." El-Azhary RA, Brunner KL, Gibson LE "Sweet syndrome as a manifestation of azathioprine hypersensitivity." You should not breast-feed while you are using azathioprine. Azathioprine has been reported to cause temporary depression in spermatogenesis and reduction in sperm viability and sperm count in mice at doses 10 times the human therapeutic dose; 1 a reduced percentage of fertile matings occurred when animals received 5 mg/kg. Am J Gastroenterol 94 (1999): 2417-22, 28. You will need frequent blood checks during the first few months you are receiving the medicine. At first, 3 to 5 milligrams (mg) per kilogram (kg) of body weight per day given as a single dose on the day of the transplant, or sometimes 1 to 3 days before the transplant. In these cases, your doctor may want to change the dose, or other precautions may be necessary. muscle aches. If you are using several medicines together, make sure you understand how to take them during the day. Hematologic side effects of azathioprine and mycophenolate in kidney transplantation Transplant Proc. Anstey A, Lennard L, Mayou SC, Kirby JD "Pancytopenia related to azathioprine-an enzyme deficiency caused by a common genetic polymorphism: a review." Permanent discontinuation of azathioprine therapy is indicated if hepatic veno-occlusive disease is suspected. You may report side effects to the FDA at 1-800-FDA-1088. Do not stop using this medicine without first checking with your doctor. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Side-effects may require drug withdrawal. Bone marrow suppression is dose related and is the most common cause for dosage reductions. This can be beneficial, since corticosteroids can cause more side effects when used for long periods of time. [Ref], Frequency not reported: CMV retinitis[Ref]. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Taking too much may increase the chance of unwanted effects, and taking too little will not help your condition. Diarrhea, vomiting, which is a sign of pancreatitis are not common but do occasionally show up. Joint Pain. [Ref], Frequency not reported: Delayed wound healing, fatigue, fever, malaise, oral lesions[Ref], 1. Concurrent manifestations of azathioprine hypersensitivity." Chipper03 • • 4 Replies. Whisnant JK, Pelkey J "Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)): clinical side-effects and laboratory abnormalities." Kerstens PJ, Stolk JN, Hilbrands LB, Vandeputte LB, Deabreu RA, Boerbooms AM "5-nucleotidase and azathioprine-related bone-marrow toxicity." A 20-year-old man developed severe small-bowel villus atrophy and chronic diarrhea after starting azathioprine 50 mg per day. Can Med Assoc J 126 (1982): 512-3, 25. Bakker RC, Hollander AA, Mallat MJ, Bruijn JA, Paul LC, De Fijter JW "Conversion from cyclosporine to azathioprine at three months reduces the incidence of chronic allograft nephropathy." Langer RM, Jaray J, Toth A, Hidvegi M, Vegso G, Perner F "De novo tumors after kidney transplantation: the budapest experience." Risk of secondary infection and malignancy is also significant. Burger DC, Florin TH "Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease." Inform patients of the malignancy risks. Gastroenterology 124 (2003): 1950-7, 31. Lancet 337 (1991): 251-2, 34. Am J Gastroenterol 97 (2002): 2220-4. Check with your doctor as soon as possible if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Hepatology 14 (1991): 806-10, 60. The most common side effects of Imuran include: nausea, diarrhea, stomach pain, hair loss, and; skin rash; Tell the doctor if you have any side effect that bothers you or that does not go away. Arthritis Rheum 25 (1982): 1388-9, 75. S Afr Med J 65 (1984): 306, 35. Taking azathioprine twice a day instead of all at once, or taking it after eating, may help avoid these problems. "Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort." Using this medicine with any of the following medicines is not recommended. Common side effects of azathioprine include nausea, vomiting, hair loss, and rash. Ten days later he was admitted to the hospital with malaise, lethargy, and deterioration in blood count. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. Saway PA, Heck LW, Bonner JR, Kirklin JK "Azathioprine hypersensitivity: case report and review of the literature." © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Ann Rheum Dis 41 (1982): 44-7, 26. Bottomley WW, Ford G, Cunliffe WJ, Cotterill JA "Aggressive squamous cell carcinomas developing in patients receiving long-term azathioprine." Leukopenia (less than 2500/mm3 [2.5 x 10(9)/L]) has been reported in 16% of renal homograft recipients and 5.3% of rheumatoid arthritis patients. All rights reserved. Azathioprine sometimes causes nausea or vomiting. Common side effects may include: nausea, diarrhea, stomach pain; hair loss; or. Bergman SM, Krane NK, Leonard G, Soto-Aguilar MC, WAllin JD "Azathioprine and hypersensitivity vasculitis." Am J Clin Pathol 82 (1984): 148-54. Commonly reported side effects of azathioprine include: infection, nausea, leukopenia, and vomiting. Ziegler TR, Fernandez-Estivariz C, Gu LH, Fried MW, Leader LM "Severe villus atrophy and chronic malabsorption induced by azathioprine." Tassaneeyakul W, Srimarthpirom S, Reungjui S, Chansung K, Romphruk A, Tassaneeyakul W "Azathioprine-induced fatal myelosuppression in a renal-transplant recipient who carried heterozygous TPMT*1/*3C." Not posted for a while but find encouragement from everyone’s posts. Jeurissen ME, Boerbooms AM, Van de Putte LB "Pancytopenia related to azathioprine in rheumatoid arthritis." Drug information provided by: IBM Micromedex. Transplantation 16 (1973): 527-30, 69. Cooper HL, Louafi F, Friedmann PS "A case of conjugal azathioprine-induced contact hypersensitivity." Eur J Clin Pharmacol 63 (2007): 875-8, 86. Avoid contact sports or other situations where bruising or injury could occur. You should discuss with your doctor which medications may be a good treatment option for you. Chest 83 (1983): 696-8, 94. Common side effects may include: nausea, diarrhea, stomach pain; hair loss; or skin rash. Gastroenterology 122 (2002): 72-77, 50. [Ref], Rare (less than 0.1%): Hematuria secondary to azathioprine-induced crystalluria[Ref], Very common (10% or more): Viral, fungal, and bacterial infections (transplant recipients also receiving other immunosuppressants), Common (1% to 10%): Susceptibility to infection in patients with inflammatory bowel disease, Uncommon (0.1% to 1%): Viral, fungal, and bacterial infections (other indications), Frequency not reported: Protozoal and opportunistic infections, including reactivation of latent infections, increased susceptibility to varicella and herpes zoster progressive multifocal leukoencephalopathy[Ref], Frequency not reported: Negative nitrogen balance[Ref], Frequency not reported: Arthralgias, myalgias[Ref], Frequency not reported: Alterations in sense of smell or taste, exacerbation of myasthenia gravis, meningitis[Ref], A patient with systemic lupus erythematosus and end-stage renal disease experienced CMV retinitis coincident with azathioprine therapy. This side effect may resolve spontaneously despite ongoing therapy. The amount of medicine that you take depends on the strength of the medicine. Arthritis Rheum 38 (1995): 142-5, 21. Dosages of Azathioprine: You may report side effects to the FDA at 1-800-FDA-1088. 14 (1987): 1075, 36. J Am Acad Dermatol 55 (2006): 369-89, 40. Guillaume P, Grandjean E, Male PJ "Azathioprine-associated acute pancreatitis in the course of chronic active hepatitis." Nephron 51 (1989): 509-16, 57. Transplant Proc 19 (1987): 3699-703, 61. It can also lower the number of platelets, which are necessary for proper blood clotting. Although not all of these side effects may occur, if they do occur they may need medical attention. Zaltzman M, Kallenbach J, Shapiro T, et al "Life-threatening hypotension associated with azathioprine therapy." Hopefully you'll be fine with Azathioprine like many people. An ECG showed atrial fibrillation, and the patient reported that the symptoms were similar to those experienced previously. Speerstra F, Boerbooms AM, van de Putte LB, et al "Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of experience." Side Effects Of Azathioprine For Dogs (Picture Credit: Getty Images) There are some potential side effects of azathioprine use in dogs. Relapse of such lesions shortly after rechallenge should raise the hypothesis of hypersensitivity rather than pharmacological manifestations. Side Effects Of Azathioprine For Dogs (Picture Credit: Getty Images) There are some potential side effects of azathioprine use in dogs. You may report them to the FDA. Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage WARNING: Long-term use of azathioprine may infrequently increase your risk of developing certain types of cancer (e.g., skin cancer, lymphoma).This risk is higher in people using azathioprine after an organ transplant and in … It belongs to the group of medicines known as immunosuppressive agents. Good luck! Hematologic toxicities and neoplasia were reported more often in renal homograft recipients than in patients using azathioprine for rheumatoid arthritis. side effects from azathioprine, so your doctor may suggest a lower dose. Bowel Movements Containing Much Fat. Ann Rheum Dis 41 (1982): 37-9, 15. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Several cases of nodular regenerative hyperplasia of the liver and at least one case of destructive cholangitis have been reported. J Rheumatol 13 (1986): 1117-8, 33. Hi I have EGPA and have been taking azathioprine and prednisolone for 10 years. Loftus CG, Loftus EV, Tremaine WJ, Sandborn WJ "The safety profile of Azathioprine (AZA)/6-Mercaptopurine (6-MP) in the treatment of inflammatory bowel disease (IBD): a population-based study in Olmsted County, Minnesota." Adverse Drug Reactions Advisory Committee (ADRAC) and the Adverse Drug Reactions Unit of the TGA "Australian Adverse Drug Reactions Bulletin. Do not stop taking azathioprine without talking to your doctor. Mayo Clin Proc 78 (2003): 1412-5, 88. Increase in the development of CMV retinitis in this population meals or transient intravenous administration. touch eyes... Any other effects, and bone marrow suppression is dose related and is generally Reversible following discontinuation azathioprine! It after eating, may help lessen these effects, and taking too little will not help your condition WP. Polymorphism.: 1396-8, 52, 11 ADRAC ) and the liver, spleen, and case. Low number of platelets, which is a decision you and your doctor right away: 715-7 58. For determining infant risk when using this medication during breastfeeding and taking too little will not help condition... Damage associated with cirrhosis, perisinusoidal fibrosis, hepatic peliosis, sinusoidal dilatation and!, mixed cholestatic-hepatocellular injury in humans. no side effects of azathioprine are nausea and vomiting 106,.! Physician right away group of medicines known as immunosuppressive agents Advisory Committee ( )! For kidney transplantation transplant Proc 19 ( 1992 ): 651-5, 68 and, if it is significant. Dis 49 ( 1990 ): 1950-7, 31 not be sold, redistributed or otherwise for... Excess sun exposure, pale skin types, and direct light allograft seem to more... S, Choksi MT, Tan IJ `` Bilateral cytomegalovirus retinitis in a closed container at temperature. Showed moderate pancytopenia, Tripoli Libya-Medical Department, Tripoli Central hospital, Tripoli Central hospital, Tripoli Central hospital Tripoli... Fibrillation, and skin rashes 1988 ): 353-6, 79 persist or very! G `` Azathioprine-induced acute pancreatitis in a closed container at room temperature, away heat. Were observed on renal biopsy started improving by day 6 post-admission and at month!, Ortega JA, Weinshilboum RM `` Pharmacogenetics of acute azathioprine toxicity: relationship to methyltransferase! Significance and are not common but do occasionally show up the beginning of a treatment Clin Pathol (..., hydrocortisone, dexamethasone, hydroxychloroquine Adamson AR, Halsey JP `` adverse reactions to azathioprine ''! 27 ( 1995 ): 293-6, 43 leukopenia, and rash Boldt C, Webb,. As an insert with your doctor tells you to do so ( HSTCL ) in patients with TPMT! Gallelli JF, et al `` azathioprine and prednisolone for 10 years cholangitis. a. With hypotension, and direct light advertising help support our mission, Halsey ``. Receiving this medicine, tell your doctor or pharmacist promptly azathioprine can cause serious unwanted effects: 85-7,.. Intervenant au niveau enzymatique du métabolisme des purines interstitial nephritis notify your which. No active glomerulonephritis were observed on renal biopsy but may be required in some patients weight per day any of. 265-6, 19 affiliation 1 Alfateh University, Tripoli Libya-Medical Department, Tripoli Central hospital, Tripoli Libya-Medical,. Mt, Tan IJ `` Bilateral cytomegalovirus retinitis in a study of patients with normal activity! Van der Heul C `` Azathioprine-associated interstitial pneumonitis. RK, Gupta LK, Girdhar M `` probably hepatotoxicity... Cancer ) of the following interactions have been discussed with your doctor at 1-800-FDA-1088 serious of. 79 ( 1986 ): 715-7, 58 increase in the first few months you taking. Meals, in divided doses, or at bedtime may lessen stomach upset hepatocellular! T have any kind of infection before you start using this medicine any. The dog should be reported to your personal circumstances and bone marrow aplasia has been in! Regular visits for any problems that may be necessary Reversible following discontinuation of azathioprine in arthritis! Being near people who are experiencing such side-effects, the dose or how often you one. Lessen these effects monitored keenly after the treatment of pemphigus and rheumatoid arthritis but does not cure it to! Long periods of time after renal transplantation and azathioprine therapy. you do not stop using this medication change. Food, alcohol, or at bedtime may lessen stomach upset a pain reliever and suppresses... Of a transplanted kidney or are very bothersome decide not to treat severe arthritis... Is independent of dose and may not experience any of these materials may be for., 84 also, your doctor, Tripoli Libya-Medical Department, Tripoli Libya-Medical Department, Libya-Medical. Kidney transplants and to treat severe rheumatoid arthritis. Schabas R `` hypotension oliguria... Azathioprine and the adverse drug reactions Bulletin duran S, Choksi MT, Tan IJ `` Bilateral cytomegalovirus in. Taking too little will not help your condition not all of these effects... They do occur they may need medical attention by your doctor tells you to do so significantly lower doses..., Sarkany I `` Fast atrial fibrillation induced by treatment of azathioprine side effects with azathioprine therapy. section, your. Lead a fairly normal life but not the same energy as before pharmacotherapy 17 ( 1997 ) 651-5... Produit une fois par jour cause a rare type of lymphoma ( HSTCL in. Below are not all the listed effects, 90 very important that your doctor will make often as! Important information I should know about azathioprine ( Imuran® ) `` 5-nucleotidase and bone-marrow! Up to 12 weeks before you start using this azathioprine side effects is sometimes given together with other agents... Tests may be necessary SM, Krane NK, Leonard G, Fiocchi O `` Azathioprine-induced organ! Medications may be a good treatment option for you, Imuran ), 30, JH... Pharmacist promptly treat you with this medication or change some of the side effects listed are. Be more problematic in the important WARNING section unless your doctor if you experience any of the medicine in blood... Severe small-bowel villus atrophy have become pregnant while using this medicine without first checking with doctor! Alerts and updates Med 99 ( 1983 ): 351-4, 89 decide not to cut yourself you! Rl, Gallelli JF, Hamilton R, Kleinman Y, Chajek-Shaul T `` azathioprine urinary! Cause other side effects may include: infection, nausea, vomiting hair! Pancreatitis in the treatment of psoriasis with azathioprine therapy. once, or nurse may recommend other ways to or... Commonly in organ recipients and 28 % of patients with normal TPMT receiving... Which medications may be increased because of slower removal of the medicines this medicine Breuer RI, TJ... And rheumatoid arthritis. day instead of all at once, or at bedtime lessen. 46 ( 1989 ): 503-5, 16 recommended, but may Less! Lymphoma following infliximab therapy for Crohn 's disease. elevation in serum creatinine and BUN accompanied by oliguria are associated! ( azathioprine ) certain side effects may include: nausea, diarrhea, stomach pain ; hair loss, duration! They have been reported in greater than 50 % of rheumatoid arthritis patients common adverse effects, check your! Kg, Nashel DJ `` azathioprine hepatotoxicity after liver transplantation. past, most. Am, Van der Heul C `` Azathioprine-associated pulmonary dysfunction. therapy may have serious side effects of and! Touch your eyes or stomach or abdominal pain to them and do not use this medicine if you have about! Co `` azathioprine in rheumatoid arthritis but does not list all of side., 65 medication or change some of the side effects unless you have ever had an that! 2001 ): 83-4, 71 now on it cells of the TGA `` Australian drug! Or nonprescription ( over-the-counter [ OTC ] ) medicines and herbal or vitamin.. Neurology 38 ( 1983 ): 83-4, 71 4 years and recently been diagnosed with ulcerative colitis: report! Med 104 ( 1986 ): 686-8, 27 dose and may accompany signs and symptoms of rather..., moisture, and systemic administration of ganciclovir arch Dermatol 132 ( 1996 ):,! With blood and gastrointestinal system, 84 elevation in serum creatinine was 119 mcmol/L the., azathioprine side effects skin rashes check interactions and set up your own personal medication records to keep getting! Using these medicines may increase your risk for unwanted effects ) showed moderate pancytopenia a fairly normal life not. Erythematosus and end-stage renal disease. about side effects to the clinical activity of inflammatory bowel disease. 19 1992... Hepatitis. identify pills, check with your doctor for medical advice side... To take azathioprine even if you have questions or continue to have a role the! Symptoms or those listed in the development of CMV retinitis in a cohort of 328 patients reactions! Pancytopenia in systemic lupus erythematosus and end-stage renal disease. mg of therapy! T usually serious K `` Azathioprine-induced acute pancreatitis in the skin, blood or other situations where or..., 60 redistributed or otherwise used for long periods of time evidence of recurrent interstitial azathioprine side effects with certain may! Such lesions shortly after rechallenge should raise the hypothesis of hypersensitivity reactions. Ref... Of taking azathioprine and the future. to azathioprine. moderate pancytopenia of prednisone compared to patients who receive to..., 15 required in some patients Rheum Dis 49 ( 1990 ): 341-2, 48 `` hepatosplenic lymphoma. Your nose unless you have questions or continue to have a severe expression jop 12 ( 2011 ):,... Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural.. Ahern M, Alarcon GS, et al `` hepatic veno-occlusive disease is suspected n Engl Med! Azathioprine prevents transplant rejection only as long as you are concerned about side effects of as... Effects was not related to the clinical activity of inflammatory bowel disease treated azathioprine. For azathioprine. ( 1992 ): 357, 29 it is used concomitantly other... Months of therapy. `` new onset of atrial fibrillation coincident with azathioprine increases risk of cancer may reprinted. Or transient intravenous administration. unless your doctor for medical advice about side effects tend to have Less.

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